BIOLOGICAL AND CHEMICAL PROPERTIES OF THE GKI PEST ALLERGEN, REPT. I

Abstract

A fraction called GKI pest-allergen, was isolated from the extract of acetone dried plague microbes (EB strain) by precipitation with ammonium sulfide (40-60% saturation). This preparation injected intradermally in a dose of 0.01 mg provoked a positive reaction in immunized guinea pigs and caused no reaction in control nonimmune animals. The pest-allergen represents a protein-polysaccharide complex, in which the protein part is the specific allergen. Preliminary experiments staged on 50 volunteers demonstrated that the pest-allergen injected intradermally is harmless for man. Pest-allergen caused a marked allergic reaction in persons inoculated with the plague vaccine intradermally and repeatedly subjected to skin vaccination.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 1963
Accession Number
AD0616768

Entities

People

  • A. V. Lobanova
  • M. D. Pryadkina
  • V. Yu. Gavrilenkova

Tags

DTIC Thesaurus Topics

  • Acetic Acid
  • Allergens
  • Animals
  • Biological Laboratories
  • Cells
  • Chemical Properties
  • Chemistry
  • Gram-Negative Bacterial Infections
  • Immunochemistry
  • Medical Personnel
  • Microbiology
  • Microorganisms
  • Polysaccharides
  • Proteins
  • Rodents
  • Scientific Research
  • Vaccines

Fields of Study

  • Biology

Readers

  • Immunology

Technology Areas

  • Biotechnology