ACUTE TOXICITY IN RATS AND RABBITS,
Abstract
Compound LF-4713 was administered orally to albino rats at dosage levels extending from 250 to 10,000 mg./kg. Pharmacodynamic and/or toxic signs were essentially absent at dosage levels through 5000 mg./kg. At 10,000 mg./kg. hypoactivity, ataxia, nasal and oral porphyrin discharge and flaccidity were observed over a 48-hour period. Three-of-five rats died within 48 hours at this dosage level. The acute oral LD50 value was 9260 (6360-13,500) mg./kg. In primary skin and dermal LD50 studies in rabbits, LF-4713 was found to be devoid of irritating properties. No pharmacotoxic signs or mortalities were observed in either experiment. Instillation of LF-4713 into the eye of albino rabbits produced a mild conjunctivitis of 48-hour duration. The results of this test indicate that LF-4713 is not an irritant to the eye mucosa of the rabbit. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 25, 1965
- Accession Number
- AD0617366