RADIATION RESPONSES OF HEMOPOIETIC COLONYFORMING CELLS DERIVED FROM DIFFERENT SOURCES,
Abstract
Hemopoietic colony-forming cells derived from adult femoral marrow, adult spleen, and fetal liver did not exhibit a uniform sensitivity to radiation when freshly explanted cells from these sources were tested in the same way for the survival of colony-forming ability after irradiation in vivo. The D sub 0 values and extrapolation numbers observed were: for adult femoral marrow, 95 = 9 rads, 1.50 = 0.54; for adult spleen, 90 = 16 rads, 0.80 = 0.46; for fetal liver, 146 = 26 rads, 1.08 = 0.50. Fourteen days after transplantation into X-irradiated (900 rads) hosts, hemopoietic colony-forming cells derived from femoral marrow, spleen, or fetal liver showed a relatively uniform, increased radiation sensitivity for cells proliferating in spleen or in marrow. The D sub 0 values and extrapolation numbers for cells proliferating in spleen were found to be: for cells derived originally from marrow, 69 = 12 rads, 0.99 = 0.42 for cells derived from spleen, 74 = 15 rads, 0.77 = 0.43; for cells derived from fetal liver, 80 = 16 rads, 0.72 = 0.42. For cells derived from fetal liver, the increase in radiation response took place during the first 6 days after transplantation of the cells into irradiated hosts. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 10, 1964
- Accession Number
- AD0617583
Entities
People
- E. A. Mcculloch
- J. E. Till
- L. Siminovitch
Organizations
- University of Toronto