EVALUATION OF SOME ANTIMOTION SICKNESS DRUGS ON THE SLOW ROTATION ROOM (NO. 1),

Abstract

A series of antimotion sickness drugs was evaluated on the human centrifuge at the Navy School of Aviation Medicine. The procedures used enabled the same stimulus to be applied to the individual subjects through the series of drug tests. A combination of hyoscine and d-amphetamine was found to be the most effective preparation. Hyoscine alone was the most effective single drug followed by d-amphetamine and meclizine Prochlorperazine was slightly effective, but chlorpromazine, thiethylperazine, and trimethobenzamide were ineffective. Hyoscine alone produced pronounced drowsiness. The combination with d-amphetamine relieved this side effect but not the vertigo and dry mouth. The advantages of the human centrifuge in the testing of antimotion sickness drugs are pointed out. (Author)

Document Details

Document Type
Technical Report
Publication Date
Mar 29, 1965
Accession Number
AD0617755

Entities

People

  • Ashton Graybiel
  • Charles D. Wood
  • Robert G. Mcdonough
  • Robert S. Kennedy

Organizations

  • Naval Aerospace Medical Institute

Tags

DTIC Thesaurus Topics

  • Aeronautics
  • Aviation Medicine
  • Centrifuges
  • Chlorpromazine
  • Rotation
  • Side Effects
  • Test And Evaluation

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Child and Adolescent Substance Abuse Science in Autism Spectrum Disorders.
  • Systems Analysis and Design