PROPOSED MODE OF ACTION OF CORTICOSTEROIDS ON THE CONNECTIVE TISSUE,
Abstract
Previously reported changes in dermal chemistry associated with cortisol administration are explained on the basis of: (1) a hormonally potentiated release of a cellular protease into the extracellular compartment of the connective tissue; (2) the limited proteolytic activation of collagenase zymogen by this protease; and (3) the digestion of insoluble collagen by the activated dermal collagenase. The dermal chemical responses of rats to cortisol were inhibited by 'Dilantin' and by age, as was the ability of the steroid to effect the release of cellular protease into the ground substance.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1965
- Accession Number
- AD0617979
Entities
People
- J. C. Houck
- Y. M. Patel