EVIDENCE FOR A ROLE OF DOPAMINE IN EXTRAPYRAMIDAL FUNCTIONS,
Abstract
Dopamine (=3-hydroxytyramine) is the immediate precursor in the biosynthesis of noradrenaline. In brain it probably also serves as a neurotransmitter, particularly in the extrapyramidal system. About 80% of the brain dopamine occur in the neostriatum. The intraneuronal localization of dopamine was demonstrated by means of histochemical techniques. Reserpine causes dopamine to disappear from the brain and produces a parkinsonian syndrome. The central actions of reserpine can be partially counteracted by increasing the concentration of dopamine in brain (through administration of the precursor L-3,4-dihydrophenylalanine=L-DOPA). In brains of parkinson patients the concentration of dopamine has been found markedly lowered; the parkinson syndrome is favourably influenced by increasing the dopamine concentration (through L-DOPA administration). (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1964
- Accession Number
- AD0617981
Entities
People
- A. Carlsson
Organizations
- University of Gothenburg