EVALUATION OF AN IMPROVED TULAREMIA DIAGNOSTIC ANTIGEN,
Abstract
Agglutinability of tularemia diagnosticum prepared from the American variant of B. tularensis was tested by scientific-practical institutions under control of the usual diagnosticum. In examining 946 sera of persons vaccinated against tularemia it was established that the greatest agglutinability was possessed by the diagnosticum from the highly virulent Schu strain (93 per cent of positive results), slightly lesser -- by that from the attenuated culture of the same strain (89per cent of positive results) and the least was possessed by the usual diagnosticums (75 per cent of positive results). The same sensitivity gradation for diagnosticums was confirmed in staging the agglutination reaction with 110 sera of patients and persons who formerly sustained tularemia, the number of sera reacting with the diagnosticums equalling 108, 107 and 105 respectively. In staging the reaction with the sera of brucellosis patients or persons who had this disease, as well as with the sera of patients with other affections (a total of 245 sera) the number of positive results equalled 28, 24 and 12 respectively. The possibility is not excluded that in individual cases these reactions are conditioned by the fact that donors sustained tularemia in the past or were vaccinated against this infection. Sera of 30 healthy persons, who never sustained tularemia and were never vaccinated against this disease failed to react with the diagnosticums. Diagnosticum prepared from the virulent American variety is recommended for detection of agglutinins in the sera with a low antibody level. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1962
- Accession Number
- AD0618870
Entities
People
- L. S. Egorova
- N. V. Panina
- O. S. Emelyanova
- O. V. Ravdonikas
- V. G. Pilipenko
Organizations
- United States Army Biological Warfare Laboratories