IMPROVEMENT OF THE NUTRIENT MEDIUM AND THE SEARCH FOR A METHOD OF PURIFYING THE PROTECTIVE ANTHRAX ANTIGEN

Abstract

As a result of work on cultivation of anthrax microbe to obtain a protective antigen a milk-peptone medium was suggested. To isolate the anthrax antigen from the culture fluid a method of its precipitation with ethyl alcohol is recommended, with subsequent concentration and stabilization of the antigen, its sorption on aluminum hydroxide and lyophilization. Chemical sorbed vaccine, obtained by the mentioned method, provoked but insignificant postvaccinal reactions, and possessed sufficiently high immunogenic properties.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1962
Accession Number
AD0619002

Entities

People

  • A. I. Filippenko
  • A. P. Budak
  • N. E. Gefen
  • N. I. Aleksandrov
  • V. A. Lebedinskiy
  • V. F. Runova
  • Yu. V. Yezepchuk

Organizations

  • United States Army Biological Warfare Laboratories

Tags

Communities of Interest

  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Aluminum
  • Animals
  • Cells
  • Hard Copy
  • Hydroxides
  • Infection
  • Laboratory Animals
  • Microorganisms
  • Precipitation
  • Russian Language
  • Saturation
  • Translations
  • United States
  • Vaccines
  • Wound Infections

Readers

  • Electrochemical Engineering/ Fuel Cell Technologies
  • Immunology

Technology Areas

  • Biotechnology