CURRENT CONCEPTS OF ACUTE CARBON TETRACHLORIDE HEPATOTOXICITY
Abstract
A literature survey of hydrocarbon-induced, experimental, acute hepatotoxicity was made. It was concluded that carbon tetrachloride, and probably other hydrocarbons, directly interfere with the selective permeability of the liver cell wall and membranous endoplasmic reticulum for electrolytes, water, and certain hydrophilic proteins. Concomitantly the toxin stimulates the sympathetic nervous system and the release of its hormones. These reduce hepatic blood flow, by vasoconstriction, thereby inducing centrilobular hypoxia, degeneration, and necrosis. These also cause massive mobilization of fats from the peripheral depots. These fats accumulate in the liver where their secretion, as triglycerides, is blocked by unknown mechanisms.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1963
- Accession Number
- AD0619415
Entities
People
- Philip W. Andrews
Organizations
- United States Air Force School of Aerospace Medicine