EFFECT OF DRUGS ON MOTOR PERFORMANCE AND RESPONSE TO AUDITORY STRESS IN MICE AND RATS.
Abstract
Mice susceptible to audiogenic seizures and normal mice were used to evaluate the anticonvulsant activity of monoamino oxidase inhibitors. Tranylcypromine, pheniprazine, etryptamine, phenelzine, and nialamide inhibited the tonic extensor component of audiogenic seizures. Iproniazid inhibited both the tonic and clonic components of audiogenic seizures. With the exception of etryptamine, none of the inhibitors was active in preventing convulsions induced by electroshock (M.E.S. Test). The incidence of audiogenic seizures in two strains of mice was found to be markedly reduced by providing an outlet for escape from a sound chamber in which the animals were exposed to intense auditory stimulation. Escape behavior was found to be inhibited by chlorpromazine, triflupromazine, and perphenazine, but not by imipramine, pentobartibal, or phenobarbital. Chlorpromazine and related analogs (perphenazine, trifluoperazine, prochlorperazine, and triflupromazine) were found to inhibit the escape response of rats from intense auditory stimulation. Phenobarbital, captodiamine, phenytoloxamine, imipramine, and phenaglycodol did not prevent escape. At high doses, carisoprodol, meprobamate, and ectylurea had a slight inhibiting effect on escape. Amphetamine and pheniprazine increased performance time of mice on the rotating rod, whereas the effects of caffeine were questionable. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1962
- Accession Number
- AD0620213
Entities
People
- Leon S. Otis
Organizations
- SRI International