ROLE OF HYPERREACTIVITY OF BRONCHIAL AND PULMONARY VASCULAR MUSCLE TO ACETYLCHOLINE AND HISTAMINE IN ANAPHYLACTIC SHOCK IN RABBITS AND GUINEA-PIGS
Abstract
The role of hyperreactivity of bronchial and vascular muscle to circulating acetylcholine (ACh) and to histamine in anaphylactic shock (AS) was investigated in rabbits and guinea-pigs. No increase in the responsiveness in intratracheal, systemic arterial and right ventricular blood pressures to ACh or histamine was observed in either species during AS. Endotoxin-induced hyperreactivity of pulmonary vasoconstrictor mechanisms to ACh in rabbits that had survived AS, demonstrated the capacity of pulmonary blood vessels to develop such a hyperreactivity. The results of the experiments indicate that hyperreactivity of bronchial or pulmonary vascular muscle to circulating ACh or to histamine does not play a role in the changes observed in arterial, right ventricular and intratracheal pressures during AS in rabbits and guinea-pigs.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1965
- Accession Number
- AD0620782
Entities
People
- G. J. Hildebrand
- J. Ng
- Y. M. Seys
Organizations
- University of California