MECHANISM OF HAEMOLYSIS BY COMPLEMENT,
Abstract
Recent studies of immune haemolysis have been concerned with isolation and characterization of intermediates, investigation of the successive steps, development of the one-hit theory, design of precise analytical methods for measurement of C'I, C'2 and C'4, and elucidation of the enzymic action of C'Ia. What was formerly known as C'3 has been resolved into five distinct factors but knowledge of the intermediate steps in this phase of the system is still sketchy. While the mechanism of cytocidal action is still unsolved, many new tools are now available for studying the nature of complement as well as its participation in immune defence, hypersensitivity reactions, autoimmune phenomena and graft rejection. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1965
- Accession Number
- AD0621458
Entities
People
- Manfred M. Mayer
Organizations
- Johns Hopkins University