A BIOASSAY OF THE PROMINENT HUMORAL AGENTS INVOLVED IN ENDITOXIN SHOCK.
Abstract
This report defines the release of neurohumoral substances into the circulation after the intravenous administration of a lethal dose of E. coli endotoxin. An isolated saphenous vein in circuit with either an intact or a surgically eviscerated dog allowed the measurement of vessel-tension changes and afforded a continuous bioassay of the existing neurohumoral balance; blocking agents were used to define the agent that was active at any one given time. Histamine, or a similar compound, was active in the first phase of shock with catecholamines playing the predominant role during the second hypotensive phase. A parasympathetic-like response (third phase), causing bradycardia and hypotension, was also noted. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1965
- Accession Number
- AD0621508
Entities
People
- James A. Vick
Organizations
- Edgewood Chemical Biological Center