FOCAL ANTIBODY PRODUCTION BY TRANSFERRED SPLEEN CELLS IN IRRADIATED MICE,
Abstract
Lethally irradiated mice were injected with various numbers of normal spleen cells, and then immunized with sheep erythrocytes. In their spleens, antibody appeared in localized areas whose number corresponded to the number of spleen cells injected. When sheep and pig erythrocytes were injected simultaneously, antibody against each was found in separate areas. From these findings it is postulated that single precursor cells are responsible for the areas of antibody, and that the progeny of each is restricted to forming a single antibody. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 20, 1965
- Accession Number
- AD0621543
Entities
People
- Ben W. Papermaster
- John H. L. Playfair
- Leonard J. Cole
Organizations
- Naval Radiological Defense Laboratory