REACTION OF 4-FORMYL-1-METHYL PYRIDINIUM IODIDE OXIME (4-PAM) WITH ISOPROPYL METHYLPHOSPHONOFLUORIDATE, GB.

Abstract

The reaction of GB with 4-formyl -1-methylpyridinium iodide oxime (4-PAM), a model treatment compound for anticholinesterase poisoning, in near-neutral aqueous solution yields O-(isopropyl methylphosphono)-4-formyl1-methylpyridinium iodide oxime (4-PPAM). Its rate of formation is defined by the relationship dx/dt = k (GB) (4-PAM anion), where k = 885 = 70/M/min, 30 C, pH 7.6, 0.1 M KNO3. 4-PPAM is stable in acidic and neutral aqueous solution. Its decomposition in alkaline solution is defined by the relationship dx/dt = k (OH) (4-PPAM), where k = 8600/M/min, 30 C, 0.1 M KC1. 4-PPAM is a potent anticholinesterase. Its decomposition in nearneutral aqueous solution is speeded by imidazole, 4-PAM, bicarbonate, and two hydroxamic acids. (Author)

Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1965
Accession Number
AD0622292

Entities

People

  • B. E. Hackley Jr.
  • G. M. Steinberg
  • J. C. Lamb
  • Scott R. Solomon

Organizations

  • Edgewood Chemical Biological Center

Tags

DTIC Thesaurus Topics

  • Acids
  • Aqueous Solutions
  • Chemical Compounds
  • Chemical Reaction Properties
  • Chemical Reactions
  • Decomposition
  • Enzyme Inhibitors
  • Hydroxamic Acids
  • Imidazoles
  • Poisoning
  • Rate Of Formation

Fields of Study

  • Chemistry

Readers

  • Analytical Chemistry
  • Neurotoxicology