THE EFFECT OF SYMPATHOMIMETIC AMINES ON FEMORAL ARTERIAL BLOOD FLOW IN THE CAT,
Abstract
Changes in the blood flow through the unopened femoral arteries of anaesthetized cats after the local intra-arterial and intravenous injection of adrenaline, noradrenaline, phenylephrine, metaraminol, methylamphetamine, mephentermine, methoxamine and isoprenaline have been determined by an electromagnetic method. The simultaneous recording of mean aortic pressure enabled changes in femoral vascular resistance to be calculated. Local intraarterial injection of isoprenaline reduced, while noradrenaline, phenylephrine, metaraminol, methoxamine and methylamphetamine increased, femoral vascular resistance. Adrenaline and mephentermine produced variable resistance changes. Those agents which increased femoral vascular resistance when given intra-arterially frequently reduced resistance when given intravenously. This reduction accompanied the rise in systemic arterial pressure, but in many animals adrenaline, noradrenaline, phenylephrine and metaraminol frequently induced a further reduction in resistance as the pressor effect declined. These observations are discussed in relation to the current theories of the mechanism of vasodilatation produced by sympathomimetic amines. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 03, 1964
- Accession Number
- AD0622542
Entities
People
- A. Kolin
- G. Ross
Organizations
- University of California, Los Angeles