Development of an Orally Effective Insect Repellent
Abstract
The objective of the program is the development of insect repellents that can be administered systemically, preferably orally. In order to study chemically induced feeding behavior of mosquitoes, chemicals that induce engorgement of mosquitoes were investigated. Although adenosine-5-monophosphate stimulates engorgement to some extent, no nucleotide or other compound tested equaled the engorgement-stimulating properties of adenosine-triphosphate. Skin permeability to various chemicals was investigated. A new assay procedure was developed in which an electronic device records the probing, penetration, salivation, engorgement, and withdrawal of a mosquito in relation to its host. Each act is distinct and can be separately recognized in the recording of a single mosquito bite. The chart recordings were correlated with the physiological events occurring within the mosquito during engorgement and salivation. Statistical methods were applied to information derived from the electronic recordings, and statistically valid criteria for assessing the repellent-attractant phenomena of chemical compounds were investigated.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 31, 1965
- Accession Number
- AD0622983
Entities
People
- Philip Kashin
Organizations
- IIT Research Institute