INCREASED PLASMA-CHOLINESTERASE ACTIVITY AND SUCCINYLCHOLINE RESISTANCE: A GENETIC VARIANT.
Abstract
Plasma-cholinesterase activity was determined in medical-volunteer-program subjects. In 1,029 subjects, activity varied from 92 to 1,278 micromoles ACH hydrolyzed/hr, with a mean of 391 micromoles. Plasmacholinesterase activity in one subject was consistently elevated. Examination of his family revelaed that this activity was inherited in an autosomal, dominant manner. In vitro and in vivo studies suggested that the propositus was heterozygous for an enzyme molecule more than three times as active as the usual cholinesterase. The pharmacological effect of this genetic variation is discussed. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1965
- Accession Number
- AD0623005
Entities
People
- Harvey W. Neitlich
- L. A. Mounter
Organizations
- Edgewood Chemical Biological Center