5-HYDROXTRYPTAMINE RECEPTORS AND SYNAPTIC TRANSMISSION IN MOLLUSCAN NEURONES,
Abstract
The high 5-hydroxytryptamine (5-HT) mollusc ganglia (which is here confirmed for the Argentine land snail Cryptomphallus aspersa), the presence of enzymes for the synthesis and inhibition of 5-HT, the specific effects of the amine on the membrane conductance of cells with inhibition of long diration (CILDA), and the presence of specific 5-HT receptors on the membrane of the same neuron type fill some of the criteria required to consider the substance as a synaptic transmitter. The blocking of 5-HT receptor sites by lysergic acid diethylamide and by bromolysergic acid was confirmed on the cellular level with CILDA neurones. Additional evidence indicates that 5-HT may be the natural excitatory transmitter for these neurones.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1965
- Accession Number
- AD0623367
Entities
People
- E. Stefani
- H. M. Gerschenfeld
Organizations
- University of Buenos Aires