UPTAKE AND EXCHANGE OF CATECHOLAMINES IN RATE TISSUES AFTER ADMINISTRATION OF D- AND 1-ADRENALINE,
Abstract
The effect of d- and 1-adrenaline (A) on the catecholamine (CA) content of heart and liver of the rat was studied at various times following i.m. administration. It was observed that both isomers are readily taken up by these tissues and exchanged for the normal neurotransmitter, noradrenaline (NA). The present experiments also present evidence for the uptake of both d- and 1-A into subcellular storage granules. The fall in the NA content of the organs was accompanied by an increased urinary excretion of NA. The present experiments also indicate that there is a slight steric preference for the storage in favor of the 1-isomer. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 30, 1964
- Accession Number
- AD0623373
Entities
People
- T. C. Westfall