EFFECT OF TYRAMINE, RESERPINE AND COCAINE ON THE NORADRENALINE RELEASE AND UPTAKE OF THE PERFUSED RABBIT KIDNEY,

Abstract

Perfusion of isolated rabbit kidneys for 120-150 min with Tyrode solution containing 0.05% iproniazide caused no change of the normal noradrenaline (NA) content. Addition of NA to the perfusion fluid caused an uptake of NA approximately proportional to the NA concentration. The major part of the NA retained was removed by subsequent perfusion with NA-free Tyrode solution. Perfusion with tyramine 0.0001 m removed a large part of the renal NA, even in the presence of NA in the perfusion fluid. Reserpine 0.000004 m did not significantly release NA or alter the renal NA content, but diminished the NA uptake from a solution containing NA. Cocaine caused a moderate release of NA and partially prevented the NA uptake while it hardly caused any loss in the renal NA content, suggesting some NA resynthesis. (Author)

Document Details

Document Type
Technical Report
Publication Date
Mar 24, 1964
Accession Number
AD0623381

Entities

People

  • A. Inouye
  • I. Tanaka

Tags

DTIC Thesaurus Topics

  • Amines
  • Aromatic Compounds
  • Catecholamines
  • Chemical Compounds
  • Diffusion
  • Norepinephrine
  • Perfusion
  • Reserpine

Fields of Study

  • Biology
  • Medicine

Readers

  • Aquatic Ecology
  • Mathematics or Statistics
  • Trauma Surgery or Emergency Medicine.