1, 1-DIMETHYLHYDRAZINE EFFECTS ON CENTRAL EXCITATORY AND INHIBITORY MECHANISMS IN CATS

Abstract

Experiments, using cats with chronically implanted brain electrodes, were performed to explore the influence of subconvulsive doses of 1, 1- dimethylhydrazine (UDMH) on certain excitatory and inhibitory mechanisms in the central nervous system (CNS). The cats were stimulated electrically in the midbrain reticular activating system, the basal forebrain inhibitory area, and both areas simultaneously while the animal was tested for performance in a positively reinforced experimental situation. UDMH was compared with amphetamine, chlorpromazine and phenobarbital both in the presence and absence of CNS stimulation. UDMH acted in a manner similar to chlorpromazine in subconvulsive doses in these tests. The most interesting and consistent effect of UDMH was to abort performance when the basal forebrain inhibitory area was stimulated. The animals resumed performance when the stimulus was terminated. UDMH has detectable CNS effects at doses well below convulsive levels.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1965
Accession Number
AD0623786

Entities

People

  • M. B. Sterman
  • M. D. Fairchild

Organizations

  • University of California, Los Angeles

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Air Force
  • Analysis Of Variance
  • Biomedical Research
  • Brain
  • Brain Stem
  • Central Nervous System
  • Central Nervous System Depressants
  • Chlorpromazine
  • Contracts
  • Electrodes
  • Governments
  • Health Services
  • Human Behavior
  • Nervous System
  • Seizures
  • Tranquilizing Agents

Fields of Study

  • Biology
  • Psychology

Readers

  • Neuroscience
  • Toxicology/Environmental Toxicology
  • Underwater engineering and Marine Technology.