A COMPARISON OF EFFECTIVENESS OF SOME ANTIMOTION SICKNESS DRUGS USING RECOMMENDED AND LARGER THAN RECOMMENDED DOSES AS TESTED IN THE SLOW ROTATION ROOM,
Abstract
In a previous study the recommended doses of some antimotion sickness drugs were tested on the Slow Rotation Room (human centrifuge). In the present study increased doses of these same drugs were used to investigate any possible increase in efficiency. Twice the dose of hyoscine (1.2 mg) failed to increase its effectiveness; however, when it was used in combination with d-amphetamine the total number of tolerated head movements exceeded the sum of that with these drugs when they were tested alone. A marked increase in effectiveness of d-amphetamine (20 mg) was noted over that in the earlier study in which a dose of 10 mg was used. Meclizine (Bonamine 150 mg), thiethylperazine (Torecan 30 mg), trimethobenzamide (Tigan 750 mg), and prochlorperazine (Compazine 15 mg) all were less effective than in the previous study when one third of these doses was used. The combination of hyoscine and d-amphetamine was the most effective drug, followed by hyoscine, d-amphetamine, and meclizine, in that order. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 16, 1965
- Accession Number
- AD0624526
Entities
People
- Ashton Graybiel
- Charles D. Wood
- Robert S. Kennedy
Organizations
- Naval Aerospace Medical Institute