MECHANISMS OF SMOOTH MUSCLE RELAXATION THROUGH THE ANODAL CURRENT STIMULATION.
Abstract
Further studies have been made on the mechanism of the smooth muscle relaxation through the anodal current stimulation. Major efforts have been concentrated in four items of research projects. The effect of (Ca++). on the action potential of the cat ureter were studied during exposure to Na(+)-free solution as well as to RingerKrebs solution. In the absense of Na+ action potential was not demonstrated at normal Ca(++) concentration, but when the external Ca(++) concentration was increased above 5 mM it recovered temporarily. The blood of elasmobranchs is isosmotic with sea water, but NaCl accounts for 50% of the osmotic solute and 38% of it is maintained by the concentrated urea molecules. Utilizing this special situation in elasmobranchs, the effect of hyper Na(+) was studied up to 200% of normal Ringer's solution with isosmotic condition. No depressant effect on transmembrane action potential was observed in hyper Na solution. By applying the suction electrode method, time course of both the depolarization and the repolarization in the in situ exposed right atrium occurred after QRS spikes in the normal condition. The region of the initial excitation was not become the initial focus of repolarization, and it is different from animal to animal. The electron microscopic structure of the nerve ending of myocardium of the mantis shrimp shows the simple and undifferentiated organizations. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 29, 1965
- Accession Number
- AD0624739
Entities
People
- Hiroshi Irisawa
Organizations
- Hiroshima University