BIOCHEMICAL AND GENETICAL STUDIES ON INH METABOLISM
Abstract
It was established that the inactivation of isoniazid in humans was a genetic trait and there was not only individual but also racial difference. The frequency distribution curve of the biologically active isoniazid serum levels 6 hours after the oral administration of 4 mg/kg of body weight of isonizzid is trimodal, corresponding to the three phenotypes of isoniazid metabolism--rapid, intermediate and slow inactivators. On the other hand, it was observed in vitro that there was very remarkable species and drug differences in the acetylation of isoniazid, sulfonamide and PABA by the liver homogenate of various kinds of animals, and the most active site of acetylation was the liver. The purpose of the present research is to examine the correlation between the blood concentration and the capacity of tissue to acetylate isoniazid using Cynomoldus monkeys as animals of experiment.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1964
- Accession Number
- AD0625941
Entities
People
- Shigeichi Sunahara