EPIDEMIOLOGICAL AND GENETICAL STUDY ON THE DRUG-RESISTANCE OF SHIGELLAE AND STAPHYLOCOCCI.
Abstract
From the in-patients of 6 city hospitals, 6,000 strains of Shigella were isolated, and their bacteriological properties and drug-resistance patterns were examined. Approximately 90% of the isolated Shigella strains were resistant to sulfanilamide (SA). Among the drug-resistant Shigella strains, 78% were resistant to chloramphenicol(CM), tetracycline(TC), streptomycin(SM) and sulfanilamide(SA). A transmissible drug-resistance factor, R(CM(s)TC(s)SM(r)SA(r) was obtained from an epidemic in Tokyo. Following the administration of tetracycline, R(CM(s)TC(r)SM(r) SA(r) was obtained from the same patients. It was found by in vitro study that R(CM(s)TC(s)SM(r)SA(r) factor was converted to R(CM(s)TC(r)SM(r)SA(r) factor in high frequency on the plate containing tetracycline. From the in-patients of 14 hospitals, 1284 strains of staphylococci were isolated, and their phase typing and drug-resistance patterns were examined. Ninety-nine percent were drug-resistant. Among the resistant strains, 31% were resistant to SA, 20% to PC.SA, 17% to TC.SM.PC.SA, and 12% to TC.PC.SA. It was noted that the degree of resistance to each drug was extremely high in the multiple resistant strains.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 14, 1964
- Accession Number
- AD0625951
Entities
People
- Susumu Mitsuhashi