EFFECTS OF PAMC1 AND TMB-4 ON NEUROMUSCULAR TRANSMISSION. II. EFFECTS ON ISOLATED RAT PHRENIC-NERVE DIAPHRAGM-MUSCLE PREPARATION.

Abstract

The effects of pyridine-2-aldoxime methochloride (PAMC1) and 1,1'-tri-methylene-bis (4-formyl-pyridinium bromide) dioxime (TMB 4) on neuromuscular transmission in the isolated rat-phrenic-nerve diaphragm preparation were studied in the absence of organophosphate anticholinesterases. Both PAMC1 and TMB-4 antagonized the initial neuromuscular block resulting from addition of depolarizing agents. After prolonged exposure to the latter, the addition of PAMC1 and TMB-4 increased the block in a manner similar to that of d-tubocurarine. Tetraethyl ammonium (TEA) antagonized the depression of response to indirect stimulation following addition of PAMC1. (Author)

Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1965
Accession Number
AD0627842

Entities

People

  • Joseph H. Fleisher
  • Niles R. Ellingson

Organizations

  • Edgewood Chemical Biological Center

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Biological Sciences
  • Chemical Compounds
  • Depression
  • Enzyme Inhibitors
  • Methylenes
  • Muscles
  • Nerves
  • Neuromuscular Transmission
  • Organic Compounds
  • Organophosphates
  • Peripheral Nervous System
  • Phrenic Nerves
  • Pyridines
  • Skeletal Muscle

Fields of Study

  • Biology
  • Chemistry
  • Medicine

Readers

  • Military Engineering.
  • Neuroscience
  • Neurotoxicology