BOTULINUM ANTITOXIN AS A THERAPEUTIC AGENT IN MONKEYS WITH EXPERIMENTAL BOTULISM

Abstract

Antitoxin administered soon after the appearance of the first toxic signs in monkeys given 2.5 to 5.0 LD50's of botulinum toxin resulted in complete recovery in 11 out of 15 animals when liquid food and fluids were forced during the period of aphagia. When no supportive treatment was applied, only one out of six survived. The survivor had received 2.5 LD50's of toxin. It is concluded that most monkeys given 2.5 to 5.0 LD50s of botulinum toxin intravenously can be saved when the antitoxin is administered soon after the first toxic signs are detected and when daily, supplemental, intragastric feedings, vitamins and antibiotics are given.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1965
Accession Number
AD0627996

Entities

People

  • Fred W. Oberst
  • James W. Crook
  • Michael J. House
  • Paul Cresthull

Organizations

  • Edgewood Chemical Biological Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Anti-Bacterial Agents
  • Antitoxins
  • Biomedical Research
  • Botulism
  • Buffers (Chemistry)
  • Digestive System Processes
  • Drug Therapy
  • Food
  • Laboratory Animals
  • Materials
  • Monkeys
  • New York
  • Patient Care
  • Rhesus Monkeys
  • United States
  • United States Government

Fields of Study

  • Biology
  • Psychology

Readers

  • Exercise and Sports Science.
  • Immunology
  • Toxicology/Environmental Toxicology