PHARMACOTOXIC EVALUATION OF NINE VEHICLES ADMINISTERED INTRAPERITONEALLY TO MICE

Abstract

The purpose of the present study was to determine the LD100 (lethal dose for 100% of the test population), LD50 (lethal dose for 50% of the test population), and ED0 (highest dose at which no effects are seen in any of the test population) for intraperitoneal injections of nine solvents into mice. A comparison of the toxicity (ED0, LD50, and LD100) of these solvents showed their descending order of toxicity to be: (1) 100% ethanol, (2) 100% polyethylene glycol-200, (3) 100% propylene glycol, (4) 100% dimethyl sulfoxide, (5) 100% sterol diluent, (6) distilled water, (7) 0.5% methylcellulose solution, (8) isotonic saline solution, and (9) 3.0% polyvinylpyrrolidone solution suspended in isotonic saline solution.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1965
Accession Number
AD0628313

Entities

People

  • C. D. Schott
  • Elmer G. Worthley

Organizations

  • Edgewood Chemical Biological Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Alcohols
  • Cellulose
  • Cellulose Ethers
  • Death
  • Dielectric Polymers
  • Lethal Dosage
  • Materials
  • Methyl Cellulose
  • Plastics
  • Polyethylene Glycols
  • Polyethylenes
  • Propylene Glycol
  • Resins
  • Rodents
  • Saline Solution
  • Sulfur Compounds
  • Toxicity

Readers

  • Analytical Chemistry
  • Toxicology/Environmental Toxicology