ON THE STUDYING OF AN ALLERGIC SKIN REACTION AS AN INDICATION OF IMMUNITY TO TULAREMIA,
Abstract
The cutaneous allergical reaction in tularemia is specific. The periodic positive reaction to brucellin in animals immune to tularemia has to be considered in practice. In guinea pigs, immune to brucellosis and tuberculosis, the allergical skin reaction, upon the introduction of tularin, was not present. Non-immune guinea pigs, given a single ordinary intracutaneous injection of tularin, responded with a transitive formation of antibodies in low titers (1:10 - 1:20). However, even multiple (during a month) intracutaneous introductions of ordinary doses of tularin did not create any allergical skin reaction in immune guinea pigs. During pathological analysis of the reaction of the skin of animals immune to tularemia, characteristics traits, which are included in the proliferation of the histocytic elements with the formation of cells of an epithelioid nature and uniting later with the lymphoid infiltration, were clarified. An allergical skin reaction to tularemia does not appear in all types of animals, in which a highly intensive immunity was experimentally obtained by recovery from the infection of tularemia. Therefore the intracutaneous tularin test for the diagnosis of tularemia cannot be utilized in all types of animals. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1966
- Accession Number
- AD0630725
Entities
People
- T. A. Kalitina
Organizations
- United States Army Biological Warfare Laboratories