MEDIAN LETHAL DOSE (LD-50/60) STUDIES IN SHEEP FOLLOWING 250-KVP X-IRRADIATION.

Abstract

Seventy-four sheep, Ovis aries, were subjected to bilateral, total-body, 250-kvp x-irradiation at a dose rate of 7.5 r/min. Doses ranging from 218 to 518 r (midline air dose) were administered at nine different dose levels. Probit analysis of the mortality data revealed a 50-percent, 60-day (LD-50/60) lethal dose value of 389 r with 95-percent confidence limits of from 334 r to 437 r. Converting midline air dose to midline tissue dose resulted in the value 245 r with limits of from 210 r to 275 r. All deaths occurred between 16 and 32 days following irradiation. Hematological studies and gross necropsies confirmed the severe involvement of the hematologic system. (Author)

Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1966
Accession Number
AD0631189

Entities

People

  • Jelle Deboer
  • Thomas S. Mobley
  • William R. Godden

Organizations

  • Air Force Research Laboratory

Tags

DTIC Thesaurus Topics

  • Computing-Related Activities
  • Confidence Limits
  • Data Science
  • Dose Rate
  • Factor Analysis
  • Information Science
  • Interdisciplinary Science
  • Lethal Dosage
  • Mathematical Analysis
  • Mathematics
  • Statistical Analysis

Fields of Study

  • Medicine
  • Physics

Readers

  • Nuclear and Radiation Engineering.
  • Toxicology/Environmental Toxicology
  • Trauma Surgery or Emergency Medicine.