PRECIPITIN RESPONSE TO HUMAN SERUM BY A RABBIT POPULATION. COMPARISON OF STRESSES ON SECONDARY PRECIPITIN RESPONSES.
Abstract
The report analyzes the secondary precipitin response of a population of rabbits subjected to various stresses and stress combinations. As administered in this experiment, the following stresses and stress combinations produced a statistically significant depression of precipitin production (compared to controls) during the anamnestic response of rabbits to a complex antigen (human serum). These are rank-ordered with the stress producing the greatest effect at the head of the list: 6-mercaptopurine; 800 r whole-body gamma radiation immediately followed by 10 days at a simulated altitude of 15,000 ft.; splenectomy followed 21 days later by 800 r of gamma radiation; 800 r whole-body gamma radiation or 15,000-ft. simulated altitude for 10 days followed by 800 r whole-body gamma radiation; and splenectomy. The following stresses showed no significant effect: 15,000-ft. simulated altitude during the induction period; 15,000-ft. simulated altitude for 10 days before the induction period; major surgery involving implantation of dosimeters. Whole-body gamma radiation (800 r) immediately followed by 15,000-ft. simulated altitude resulted in a mortality of 58% within the first 48 hours of decreased atmospheric pressure. Altitude exposure before 800 r gamma radiation did not indicate any synergism or antagonism related to the anamnestic response. Stress did not appear to increase antibody levels in the absence of a booster injection. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1966
- Accession Number
- AD0632250
Entities
People
- G. Bonar Sutherland
- W. G. Glenn
Organizations
- University of Saskatchewan