ANNUAL REPORT (2ND), MARCH 23, 1966 ON Contract Number DA-18-035-AMC-124(A) (Albany Medical College of Union Univ., NY)
Abstract
Following intravenous administration of toxin to albino rats, there appeared to be a reduction in the concentration of toxin within the blood within four hours. Analyses of the gross components of the blood have indicated that the toxin is carried in the fluid portion of the blood. Some toxin may be adsorbed on the surface of the red blood cell, but does not penetrate it, and can be eluted from the surface with saline. Clotting did not remove the toxin from the serum. When large oral doses of crude toxin were given to rats, there was apparently very little absorption from the gastrointestinal tract. Assays of plasma in mice at times up to four hours after oral administration were generally negative, although the contents of the gastrointestinal tract remained lethal to mice. In spite of the apparent poor absorption, there was indication of accumulation of toxin in the kidneys. Following intraperitoneal injection of the toxin into rats, the mouse assay of the plasma became positive within 30 minutes. The contents of the gastrointestinal tract also became lethal within 30 minutes. There was apparent reduction in the blood level of the toxin within four hours and accumulation of the toxin by the kidneys.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1966
- Accession Number
- AD0634374
Entities
People
- Frederick Coulston
Organizations
- Albany Medical College