BLOOD COAGULATION FACTOR ACTIVITY IN ENDOTOXEMIA
Abstract
Twelve dogs were subjected to endotoxemia and the activity of coagulation factors was studied quantitatively. Coagulation studies were performed on the dogs' normal plasma and on plasmas collected 5 minutes and 4 hours after endotoxin administration. All dogs had coagulation abnormalities 4 hours after endotoxin, and six of the twelve had abnormalities 5 minutes after endotoxin. With the exception of the platelet counts, the coagulation abnormality at 5 minutes and 4 hours was similar. It was characterized by a prolongation of the one-stage prothrombin time and/or partial thromboplastin time, a slight reduction in fibrinogen concentration, and a variable degree of deficiency in the activity of factors II, V, VII, VIII, IX, X, XI, and XII. this study does not define the mechanisms by which the activity of these factors are reduced; however, the several possible mechanisms are discussed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1966
- Accession Number
- AD0634652
Entities
People
- Paul B. Jennings
- Robert L. West
Organizations
- Walter Reed Army Institute of Research