MEASUREMENT OF LEFT CIRCUMFLEX CORONARY FLOW, CARDIAC OUTPUT, AND CENTRAL AORTIC PRESSURE IN THE UNMEDICATED GREYHOUND DOG,
Abstract
To study coronary flow dynamics under basal and changing environmental conditions, it was necessary to develop a standard animal preparation in which left circumflex coronary flow, phasic systemic cardiac output, and central aortic pressure could be measured in the awake, unmedicated state. A technique involving the surgical implantation of electromagnetic flow probes and chronic sampling catheters was successfully applied to nine greyhound dogs. Left circumfles coronary artery (LCCA) flow data, cardiac output, and central aortic blood pressure determinations are presented. In addition, coronary sinus blood determinations for five of the animals (together with the flow data) are included. LCCA flow ranged from 57 to 130 ml/min (35 to 57 ml/100 gm left ventricle/min.). Twenty to forty-seven per cent of flow occurred during left ventricular systole. Oxygen usage ranged from 7.6 to 11.9 ml/min (4.8 to 9.8 ml/100 gm left ventricle/min). The LCCA flow patterns and the range of flow values agree closely with those reported previously by Gregg. It was felt that our measurements were made in the resting but not necessarily basal state. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- May 02, 1966
- Accession Number
- AD0634922
Entities
People
- E. Peter Beck
- Leroy S. Wirthlin
Organizations
- Naval Aerospace Medical Institute