STUDIES ON THE RADIOSENSITIVE PHASE OF THE PRIMARY ANTIBODY RESPONSE. II. THE EFFECT OF MACROPHAGES FROM IRRADIATED DONORS ON ABILITY TO TRANSFER ANTIBODY FORMATION.
Abstract
Peritoneal exudate cells were harvested from rabbits which had received 450, 550, or 750 R x-irradiation twenty-four hours previously. After incubation with bovine gamma globulin these cells were injected into normal rabbits. When donors had received 750 R, no antibody response was elicited in the recipients. The response to sensitized irradiated macrophages which had received 450 or 550 R was varied. In no case did the degree of antibody response appear to depend on the number of sensitized cells injected. Irradiated recipients receiving sensitized irradiated macrophages (550 R) together with lymph node cells from normal rabbits were unable to form antibody. The implications of these findings in relation to the radiosensitive phase of the antibody response are discussed. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 13, 1966
- Accession Number
- AD0635598
Entities
People
- James F. Pribnow
- Myron S. Silverman
Organizations
- Naval Radiological Defense Laboratory