CARDIAC OUTPUT AND REGIONAL BLOOD FLOW IN THE ANESTHETIZED BABOON.
Abstract
Cardiac output and regional blood flow measurments were made in 9 normal, anesthetized, adult baboons by the use of radioactive tracers. Essentially, the method consists of rapidly introducing a solution of rubidium (Rb86) chloride into a femoral vein while serially sampling blood flow at the femoral artery. Thirty seconds after the injection of the radioactivity, the animal is sacrificed by the rapid injection of 10 cc. Lethol. This results in the production of a dye dilution curve which, by the employment of a modified Fick equation, provides the measurement of the cardiac output over the sampling period. It also results in the deposition of radioactive rubidium in the capillary beds of all tissues except the brain in direct proportion to the blood flow to that organ over the same time period. From this information, the percent of cardiac output to each tissue bed may be determined and, when calculated on the basis of the cardiac output over the same period of time, actual blood flow in centimeters per minute may be obtained. By this technic, blood flow to the following tissues was obtained: heart, lungs, liver, gut, spleen, stomach, adrenals, kidneys, throid, omentum, skin, and skeletal muscle and bone. These data are compared with similar data for the dog and man. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1966
- Accession Number
- AD0635613
Entities
People
- William P. Fife
Organizations
- United States Air Force School of Aerospace Medicine