RIBO NUCLEIC ACID CHEMISTRY: A MODEL SYSTEM FOR RIBONUCLEIC ACID DEPOLYMERIZATION AND HYDROLYSIS.

Abstract

The report summarizes evidence based on the kinetic behavior of ribonucleic acid model systems that a strong stereoelectronic effect operates in nucleophilic attack on phosphorus. The origin of this effect was ascribed to the geometric requirements of pl bond formation pi between phosphorus and oxygen. This theory was investigated by X-ray diffraction studies of the moleuclar structure of a suitable compound. (Author)

Document Details

Document Type
Technical Report
Publication Date
Jun 30, 1966
Accession Number
AD0637564

Entities

People

  • James R. Cox Jr

Organizations

  • Georgia Tech

Tags

DTIC Thesaurus Topics

  • Acids
  • Chemical Compounds
  • Chemical Synthesis
  • Chemistry
  • Depolymerization
  • Diffraction
  • Hydrolysis
  • Nucleic Acids
  • Phosphorus
  • Polymer Chemistry
  • Ribonucleic Acids
  • X Rays
  • X-Ray Diffraction

Fields of Study

  • Chemistry

Readers

  • Molecular and Cellular Biochemistry
  • Organic Chemistry
  • Theoretical Analysis.

Technology Areas

  • Biotechnology