A STUDY OF THE DYNAMICS OF THE BACTERIOLOGICAL PROCESS DURING TREATMENT OF EXPERIMENTAL TULAREMIA WITH KANAMYCIN, CHLORTETRACYCLINE AND STREPTOMYCIN

Abstract

Guinea pigs infected with lethal doses of tularemia bacteria displayed a marked decrease in number of bacteria in organs and tissues after administration of Kanamycin, chlortetracycline or streptomycin was begun at the height of the fever, about the fourth day. After the 10-day treatment was discontinued most animals were found free of bacteria; however, some suffered recurrence with some increase in number of bacteria in the organs. Kanamycin and streptomycin yielded best results. Chlortetracycline treatment was more difficult and less effective because of the insufficient dosage and treatment time used because of its toxicity for guinea pigs.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1966
Accession Number
AD0637626

Entities

People

  • Ye. M. Tsvetkova

Organizations

  • United States Army Foreign Science and Technology Center

Tags

DTIC Thesaurus Topics

  • Animals
  • Anti-Bacterial Agents
  • Bacteria
  • Cells
  • Dilution
  • Diseases And Disorders
  • Dynamics
  • Infection
  • Lethal Dosage
  • Lymph Nodes
  • Lymphatic System
  • Microbiology
  • Rodents
  • Tickborne Diseases
  • Toxicity
  • Wound Infections

Fields of Study

  • Biology

Readers

  • Mathematics or Statistics
  • Microbial Pathology
  • Oncology