COMBINED TREATMENT OF EXPERIMENTAL MELIODOSIS WITH ANTIBIOTICS AND SULFADIMESIN
Abstract
Of nine tested drugs, the greatest therapeutical effect in the treatment of melioidosis was obtained with levomycetin(chloramphinicol), sulfodimezin(sulfamethazine) and chlortetracylein; 75% to 90% of the white mice, treated with these substances, remained alive. Tetracyclin and oxytetracyclin, even though they do have some therapeutical effect, have much weaker effect than levomycetin, sulfodimezin and chlortetracyclin. Monomycin, bicyllin, streptomycin and mycerin, under same experimental conditions, have weak therapeutical effect and in practice their use should be considered unsuitable. Sulfodimerin therapy, combined with monomycetin, tetracyclin, oxytetracylcin, bicyllin, streptomycin, mycerin and levomycetin, in treatment of animals infected with melioidosis, under the conditions of the experiments, should be considered as irrational. The combined administration of sulfodimezin with chlortetracyclin guarranttees a high percentage of survival of animals (90%) and a considerable prolongation of the average life span of the mice.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 22, 1966
- Accession Number
- AD0638191
Entities
People
- E. D. Shkurko
- E. I. Kuptsevich
- E. K. Demidova
- L. A. Smirnova
- L. E. Khudanov