COCCIDIOIDOMYCOSIS: STUDIES OF CANINE VACCINATION AND THERAPY
Abstract
A 3-phase study of vaccination and antibiotic therapy in experimental pulmonary coccidioidomycosis of dogs was made to determine (a) the efficacy of various routes of inoculation of a formaldehyde-killed arthrospore vaccine, (b) the combined effects of vaccination and oral amphotericin B therapy administered immediately following respiratory exposure to Coccidioides immitis, and (c) renal damage or nephrotoxicity resulting from oral amphotericin B therapy. Neither of the pulmonary routes of vaccination (aerosol or intratracheal), either singly or in combination with oral amphotericin B therapy (150 mg per day for 20 days following challenge), provided protection against a subsequent respiratory challenge of approximately 80,000 C. immitis arthrospores. Neither subcutaneous vaccination nor therapy alone provided protection. However, 8 of 12 dogs receiving both subcutaneous vaccination and therapy completely resisted the respiratory challenge. The remaining 4 exhibited very minimal, self contained disease. Histopathological examination revealed no renal damage or nephrotoxicity in any of the dogs receiving amphotericin B in a total dose of more than 3 g, and their blood urea nitrogen levels remained within normal limits.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 27, 1964
- Accession Number
- AD0638550
Entities
People
- E. P. Lowe
- J. L. Converse
- J. T. Sinski
- M. W. Castleberry
- S. P. Pakes
Organizations
- United States Army Biological Warfare Laboratories