MORPHOLOGICAL AND BIOCHEMICAL EFFECTS OF CLOSTRIDIUM PERFRINGENS ALPHA TOXIN ON INTACT AND ISOLATED SKELETAL-MUSCLE MITOCHONDRIA.

Abstract

Electron-dense deposits were observed in skeletal-muscle mitochondria exposed in vivo and in vitro to a partially purified Clostridium perfringens alpha toxin. Depressed oxidative functions in the toxin-exposed, isolated mitochondria were concomitant with the electron-dense deposits. The mitochondria are suggested as the cellular site of action of the alpha toxin. (Author)

Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1966
Accession Number
AD0638788

Entities

People

  • Bertram Sacktor
  • Dale H. Heitkamp
  • I. William Grossman

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Biological Sciences
  • Cells (Biology)
  • Cellular Structures
  • Clostridium
  • Cytoplasm
  • Cytoplasmic Structures
  • Electrons
  • Intracellular Space
  • Mitochondria
  • Muscles
  • Organelles
  • Skeletal Muscle
  • Subcellular Fractions

Fields of Study

  • Biology

Readers

  • Cardiovascular Physiology
  • Game Theory.
  • Microbial Pathology

Technology Areas

  • Microelectronics