BOTULINUM TOXOIDS
Abstract
Procedures were developed for preparation of purified, aluminum- phosphate-adsorbed, univalent, bivalent, and pentavalent botulinum toxoids for the immunization of man. All preparations were well tolerated and elicited satisfactory antitoxin responses in man, whether administered as a single antigen or in combination. Four separate pentavalent type ABCDE toxoids produced immune responses to each antigen in a considerable proportion of individuals following an initial series of three injections. A booster injection administered 1 year after the initial injection markedly increased the antitoxin titers, and measurable antitoxin titers were found in 86 to 100 percent of the individuals immunized. The toxoids were antigenic for mice, guinea pigs, and rabbits. In guinea pigs, the toxoids afforded a high level of resistance to challenge by toxins administered by various routes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1964
- Accession Number
- AD0638933
Entities
People
- Matteo A. Cardella
Organizations
- United States Army Biological Warfare Laboratories