SUPPRESSION OF HEMOPOIETIC COLONY-FORMING UNITS IN MICE BY GRAFT-VERSUS-HOST REACTIONS.
Abstract
Attempts to characterize the time course of parental-versus-F1 hybrid immunological reactions in sublethally irradiated mice have resulted in the following observations: (1) It was possible to reverse the lethal effect of the reaction by means of a second dose of X rays delivered up to 4 days after injection of the parental lymphoid cells. In contrast, mice irradiated 5 days or later succumbed to the disease. (2) Non-irradiated host type colony-forming units in the spleens of mice undergoing the parental F1 hybrid disease were depleted at 5 days, and in the marrow by 7 days. (3) It was not possible to reverse the lethal course of the disease with large doses of host type hematopoietic cells injected 3 to 6 days after injection of the parental cells. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 22, 1966
- Accession Number
- AD0639447
Entities
People
- Leonard J. Cole
- William E. Davis Jr.
Organizations
- Naval Radiological Defense Laboratory