MODE OF ACTION OF AN INHIBITOR FROM AGAR ON GROWTH AND HEMAGGLUTINATION OF GROUP A ARBOVIRUSES

Abstract

A polysaccharide obtained from agar, and having properties similar to a previously described sulfated polysaccharide, was observed to inhibit growth and hemagglutination of some group A arboviruses. The evidence presented confirms that the inhibitory activity, in part, is the result of direct interaction between the agar polysaccharide (AP) and free virus particles. Additional evidence indicates that inhibition of viral growth also occurs as the result of interaction between AP and the chick-fibroblast cells used for propagation of the virus. The possibility was considered, therefore, that at least two different inhibitors could be present in AP-one that reacts directly with the virus particle and another that reacts with host cells. AP does not induce the production of interferon in the test system used.

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Document Details

Document Type
Technical Report
Publication Date
Apr 02, 1965
Accession Number
AD0639455

Entities

People

  • Jane B. Idoine
  • Julio I. Colon
  • Orville M. Brand
  • Richard D. Costlow

Organizations

  • United States Army Biological Warfare Laboratories

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Albumins
  • Antigens
  • Arbovirus Infections
  • Blood
  • Blood Cells
  • Cells
  • Chemistry
  • Encephalitis
  • Equine Encephalitis
  • Interferon
  • Materials
  • Microbiology
  • Physical Properties
  • Proteins
  • Virion
  • Virology
  • Viruses

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Infectious Disease/Epidemiology
  • Molecular and Cellular Biochemistry