LYMPHATIC ABSORPTION OF DRUGS.
Abstract
A survey of the role of the lymphatics in absorption from the gut indicates that these vessels may serve as an accessory route for direct absorption from the gut of some drugs but not others. Lymph was collected from the abdominal portion of the left thoracic duct of the rat, under ether anesthesia, by means of an indwelling catheter, fabricated of polyethylene or silastic tubing. Catheterization was carried out without the necessity of feeding fat, saline or any other fluid. Drugs were administered in solution by intraintestinal or intravenous injection. Following surgery the rat was placed in a specially designed holder, allowed to recover from anesthesia and to freely drink fluid (saline or water). Lymph was collected serially over periods of 3-4 hours or overnight; flow averaged about 2 ml/hr. Blood samples were also taken at appropriate intervals. Concentration of a drug in blood and lymph was' determined by spectrophotometric or isotopic methods, previously shown to be specific for the unchanged drug. The data obtained indicated that the lymphatics are involved in both the absorption and distribution of p-amino salicylic acid. In contrast, the lymphatics appear to play no role in the absorption of quaternary ammonium drug, benzomethamine or that of sulfermerazine and triamterene. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1966
- Accession Number
- AD0640632
Entities
People
- Ruth R. Levine
Organizations
- Boston University