A METHOD OF DETERMINING SENSITIVITY OF RICKETTSIA BURNETI TO ANTIBIOTICS IN VITRO

Abstract

A method was suggested for determining the activity of antibiotics with respect to Rickettsia Burneti in vitro in cells of chicken fibroblasts. The activity of the antibiotics is determined from the difference in the amount of cells intently affected by Rickettsia in the control culture and in the culture undergoing the action of antibiotics. The effect of antibiotics is manifest in a sizable reduction of the propagation of Rickettsia Burneti in the cytoplasm of fibroblasts, a reduction in number of Rickettsia-affected cells, and in the elimination of the cytopathogenic effect of Rickettsia on cells of tissue cultures.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1964
Accession Number
AD0641752

Entities

People

  • E. P. Savitskaya

Organizations

  • United States Army Biological Warfare Laboratories

Tags

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Bacteria
  • Biological Laboratories
  • Cells
  • Citric Acid
  • Culture Techniques
  • Fibroblasts
  • Glutamic Acid
  • Gram-Negative Bacterial Infections
  • Infection
  • Infectious Diseases
  • Microbiology
  • Microorganisms
  • New York
  • Sensitivity
  • Tissue Culture
  • United States

Fields of Study

  • Medicine

Readers

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