EVALUATION OF RADIOPROTECTIVE ACTIVITY OR PROPERTIES OF SELECTED CHEMICAL COMPOUNDS IN LARGE ANIMALS.
Abstract
The objective of the research was to investigate and evaluate the radioprotective activity and properties of selected chemical compounds in large animals, and to gain insights into their mechanism of action. With respect to chemical radioprotection efforts were directed toward three general areas: (a) Studies on Compound WR-1607 in lethally X-irradiated dogs (beagles as well as mongrels) and the possibilities of combinations of other compounds with WR-1607; (b) The protective effect of small external lead cuffs, alone or in combination with chemicals, in dogs; and (c) Studies on chemical radio-protection in mice, employing hemopoietic colony-forming units (CFU) as the endpoint. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1966
- Accession Number
- AD0642313
Entities
People
- E. L. Alpen
- Leonard J. Cole
Organizations
- Naval Radiological Defense Laboratory