TISSUE MONOAMINE OXIDASE INHIBITIONS BY CONVULSIGENIC DOSES OF HYDRAZINES AND RELATED B6-HYDRAZONES.
Abstract
Convulsigenic doses (0.42 to 1.68 mM./kg.) of the pyridoxal hydrazone of unsymmetrical dimethylhydrazine (UDMH) I.P. produced from 13% to 32% inhibition of rat brain monoamine oxidase (MAO). Administration of the hydrazones of monomethylhydrazine (MMH) and of hydrazine (H) produced mild to severe convulsions, but little or no tissue MAO inhibitions. Pyridoxal (PAL) plus UDMH I.P. led to more severe convulsions than caused by UDMH alone. MAO inhibitions also increased. In contrast, pyridoxine (PIN) plus UDMH I.P. prevented UDMH convulsions, and tissue MAO inhibitions were negligible. PAL markedly decreased the MAO inhibition activity of MMH in brain and liver tissues, but not the convulsigenic activity of MMH. PIN prevented MMH convulsions reducing liver, but not brain, MAO inhibitions due to MMH. There was no consistent relationship between MAO inhibitions and the convulsigenic properties of the hydrazines and hydrazones studied. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1966
- Accession Number
- AD0643309
Entities
People
- Arthur A. Wykes
Organizations
- United States Air Force School of Aerospace Medicine