A NEW SYNTHESIS OF 2-PYRIDINE ALDOXIMES

Abstract

The use of 2-pyridine aldoxime methochloride (2-PAM) in the treatment of organophosphorus poisoning has stimulated interest in finding new convenient routes for the synthesis of the precursor 2-pyridine aldoximes. We have found that the reaction of 2-chloromethyl pyridines with buffered solutions of aqueous hydroxylamine gives good yields of the corresponding 2-pyridine aldoximes.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 1966
Accession Number
AD0643504

Entities

People

  • Arthur B. Ash
  • Brennie E. Hackley Jr.
  • Francis A. Daniher

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Alcohols
  • Amines
  • Anhydrides
  • Biomedical Research
  • Chemical Compounds
  • Chlorides
  • Maryland
  • Melting
  • Melting Point
  • New York
  • Poisoning
  • Precursors
  • Pyridines
  • Sodium Hydroxide
  • United States
  • United States Government

Fields of Study

  • Chemistry

Readers

  • Neurotoxicology
  • Organic Chemistry